UJI EFEKTIFITAS ANTIHIPERURISEMIA EKSTRAK DAUN JAMBU BIJI (PSIDIUM GUAJAVA L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR (RATTUS NORVEGICUS)

The prevalence of gout in the East Java is 7,1%. Guava leaves have the potential to reduce uric acid with a flavonoid content of 5.7% and a tannin content of 7,82%. The purpose of this study was to determine the anthihyperuricemic activity of guava leaf (Psidium guajava L.) in reducing uric acid levels in male white rats of wistar strain (Rattus norvegicus ) that had been hyperuricemic. The extract was made by maceration method using 70% ethanol as solvent. Rats were divided into 5 treatment groups. Each rat was induced with chicken liver. Data were collected using a photometer on D0, D13, and D25. Data analysis was carried out using ANOVA and test post hoc LSD. The results obtained at a dose of 800 mg/kg bw had the effect of reducing uric acid levels by 58,29%, extract dose of 400 mg/kgbw with a percent decrease in uric acid levels 53,56% and an extract dose of 200 mg/kgbw with a percent decrease in uric acid levels by 49,21. The results showed
that guava ethanol extract can reduce uric acid levels in rats and a dose of 800 mg/kgbw can reduce uric acid levels almost the same as allopurinol 100 mg.
Keywords: Anthiperuricemia, guava leaves,uric acid