PENAMBATAN MOLEKULER FOSFODIESTERASE TIPE 5 OLEH SENYAWA AKTIF ICARIIN SEBAGAI TERAPI DISFUNGSI EREKSI

Erectile dysfunction is caused by the high activity of type 5 phosphodiesterase (PDE5), which leads to a decrease in the breakdown of cGMP, continuous relaxation of smooth muscles
of the penis, and imperfections of the penis. PDE5 needs to be inhibited in cGMP degradation in order for cGMP levels to increase and cause smooth muscle contractions to last longer so that the penis can get an erection. Icariin has been reported to have properties as an aphrodisiac, however
the interaction and bioactivity effect of such compounds on the PDE5 enzyme is not yet known. The purpose of this study was to see if the bioactive compound icariin could treat erectile dysfunction by interfering with the enzyme PDE5. This study used several software programs, including PyRx, Discovery Studio Visualizer, AutoDock Tools, AutoDock Vina, and Ligplot+. The receptor is PDE5 with the code PDB:2H42 and the comparative ligand is sildenafil. The results of the mooring of molecules were analyzed using the parameters of energy affinity (ΔG). The interactions that occur are the presence of hydrogen carbon bonds, pi-sigma bonds and alkyl bonds. Icariin compounds are able to inhibit the activity of the PDE5 enzyme with a docking value of -9.2 kcal / mol while sildenafil inhibits the activity of the PDE5 enzyme with a docking value of -8.2 kcal / mol. In conclusion, icariin has the ability to inhibit the enzyme PDE5 in erection treatment.