EKSTRAK DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) SEBAGAI KANDIDAT TERAPI KOLITIS ULSERATIF PADA MENCIT YANG DIINDUKSI ASAM ASETAT 3 %

Ulcerative colitis can lead to reduced quality of life and CRC (colorectal cancer) can occur. Inflammatory Bowel Disease (IBD) is a chronic disease that occurs in the gastrointestinal tract, is in remission and relapses with the exact cause of which until now has not been clearly
identified. Binahong leaf extract (Anredera cordifolia (Ten.) Steenis) has been shown to have an anti-inflammatory effect. The purpose of this study was to determine the effect of flavonoids from binahong leaf extract on colonic inflammatory conditions and behavioral disorders in mice under KU conditions induced by 3% acetic acid. The research method used is pure experimental research. Phytochemical screening on binahong leaves was carried out using a qualitative method. The test animals used were 30 male mice (Mus Musculus), divided into 6 groups randomly which were given different treatments. Normal group (Na CMC 1%), negative control group (3% acetic acid and 1% Na CMC), positive group (3% acetic acid and dexamethasone 2 mg/kg BW
s.c), and binahong leaf extract dose of 0.728 mg, 1.456 mg, 2.912 mg, colonic conditions and behavioral tests were carried out from the beginning of induction to treatment. The results showed that In phytochemical screening, there are flavonoid compounds that have anti-inflammatory
properties dan there was an effect of binahong leaves extract on KU conditions by testing the behavior of mice and the condition of the colon of mice. MBT and TST showed significantly different results and in colonic condition, there was weight gain, normal stool consistency, and no
presence of blood.