FORTIFIKASI YOGURT EKSTRAK DAUN BINAHONG (Anredera cordifolia (Ten).Steenis) SEBAGAI KANDIDAT TERAPI KOLITIS ULSERATIF PADA MENCIT YANG DI INDUKSI ASAM ASETAT 3 %

Ulcerative Colitis (UC) is a transmural inflammatory disorder that occurs in the large intestine. The active substance of binahong leaf flavonoids is known to have anti-inflammatory activity. An innovation that can be applied to exploit the potential of binahong leaves is the fortification technique. Fortification is the process of enriching food with the addition of micronutrients. The aim of this study was to examine the anti-inflammatory effect of Yogurt Fortified of Binahong Leaf Extract (YFBLE) against ulcerative colitis mice induced by 3% acetic acid, through
hispathological and behavioral analysis. Experimental research with posttest design with control group. The study was conducted with various doses of YTEDB with a concentration of 0.5 mg, 1 mg, 2 mg and a positive control of dexamethasone. The results of the study with phytochemical analysis of binahong leaf extract (Anredera cordifolia) resulted in the presence of flavonoid compounds, alkaloids, tannins and saponins in the binahong leaf extract. The results of the yogurt analysis test include pH analysis and acid titration with the results of a relatively small decrease while the results of microbial analysis do not have other microbial contamination, proximate analysis includes water content and ash content with relatively high water content and normal ash content and for viscosity analysis the results are obtained. not good. The conclusion of this study is that YTEDB has anti-inflammatory activity for ulcerative colitis but it is less significant. Keywords: Ulcerative Colitis, Binahong, Yogurt.