UJI AKTIVITAS ANTIHIPERKOLESTEROLEMIA EKSTRAK ETANOL BUNGA PUKUL EMPAT (MIRABILIS JALAPA L) TERHADAP TIKUS PUTIH JANTAN YANG DIINDUKSI MAKANAN LEMAK TINGGI

In Indonesia, the incidence of hypercholesterolemia at the age of more than 25 years reached 36% there was an increase at the age of 55-64 years to 15.5%. The therapy used is to use statin-group drugs. The four o'clock flower ethanol extract (Mirabilis jalapa L) is thought to be efficacious as an antihypercholesterolemia, because it contains compounds that can inhibit HMG-CoA reductase which is efficacious as an antihypercholesterolemia. The purpose of this study was to determine the presence of antihypercholesterolemia activity of ethanol extract of flowers at four o'clock (Mirabilis jalapa L) against a decrease in cholesterol levels in male white rats induced by high fat food. This study was an experimental study using a pre-post test with control group design using 25 male white rats of the wistar strain which are divided into 5 groups of 5 rats each. Data analysis using repeated measures ANOVA. Results showed no significant differences meaningfully with p values >0.05, namely in extract doses of 300 mg / kgBB, 600 mg / KgBB, 1200 mg / KgBB with significant values of p 0.118, p 0.125 and p 0.653. The most effective extract in lowering total cholesterol levels was found in extracts at a dose of 1200mg/ KgBB with a significant value of p 0.653 with a mean difference of 2.800 and did not differ significantly from simvastatin.
Keywords: Hypercholesterol, Four o'clock Flowers, Repeated ANOVA